What causes Dupuytren's?

The cause is unknown. However, a family history of Dupuytren's makes you more likely to
develop the condition. One investigative study of Dupuytren's patients showed 68% of
relatives also having a history of the condition. This "genetic predisposition" amongst
relatives suggests a single gene is probably responsible. No link to any particular
occupation or line of work, or any possible past trauma to the hand, has been found.

The condition becomes more common after the age of 40. Men can be up to ten
times more likely than women to develop the condition. Also, the disease occurs
earlier in life in men than in women. The condition is very rare in young people.
Associated diseases suspected as being risk factors include a history of alcoholism,
diabetes, and epilepsy. Smoking is also considered to be a risk factor.